@article{deiana_new_2023,

title = {A new G-quadruplex-specific photosensitizer inducing genome instability in cancer cells by triggering oxidative DNA damage and impeding replication fork progression},

author = {Marco Deiana and José María Andrés Castán and Pierre Josse and Abraha Kahsay and Darío Puchán Sánchez and Korentin Morice and Natacha Gillet and Ranjitha Ravindranath and Ankit Kumar Patel and Pallabi Sengupta and Ikenna Obi and Eva Rodriguez-Marquez and Lhoussain Khrouz and Elise Dumont and Laura Abad Galán and Magali Allain and Bright Walker and Hyun Seo Ahn and Olivier Maury and Philippe Blanchard and Tangui Le Bahers and Daniel Öhlund and Jonas von Hofsten and Cyrille Monnereau and Clément Cabanetos and Nasim Sabouri},

url = {https://academic.oup.com/nar/article/51/12/6264/7160217},

doi = {10.1093/nar/gkad365},

issn = {0305-1048, 1362-4962},

year  = {2023},

date = {2023-07-01},

urldate = {2024-11-16},

journal = {Nucleic Acids Research},

volume = {51},

number = {12},

pages = {6264–6285},

abstract = {Abstract 

 Photodynamic therapy (PDT) ideally relies on the administration, selective accumulation and photoactivation of a photosensitizer (PS) into diseased tissues. In this context, we report a new heavy-atom-free fluorescent G-quadruplex (G4) DNA-binding PS, named DBI. We reveal by fluorescence microscopy that DBI preferentially localizes in intraluminal vesicles (ILVs), precursors of exosomes, which are key components of cancer cell proliferation. Moreover, purified exosomal DNA was recognized by a G4-specific antibody, thus highlighting the presence of such G4-forming sequences in the vesicles. Despite the absence of fluorescence signal from DBI in nuclei, light-irradiated DBI-treated cells generated reactive oxygen species (ROS), triggering a 3-fold increase of nuclear G4 foci, slowing fork progression and elevated levels of both DNA base damage, 8-oxoguanine, and double-stranded DNA breaks. Consequently, DBI was found to exert significant phototoxic effects (at nanomolar scale) toward cancer cell lines and tumor organoids. Furthermore, in vivo testing reveals that photoactivation of DBI induces not only G4 formation and DNA damage but also apoptosis in zebrafish, specifically in the area where DBI had accumulated. Collectively, this approach shows significant promise for image-guided PDT.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{josse_structural_2020,

title = {Structural Control of the Molecular Packing and Dynamics of Mechanofluorochromic Materials Based on Small Donor–Acceptor Systems with Turn‐On Luminescence},

author = {Pierre Josse and Magali Allain and Jan Patrick Calupitan and Yue Jiang and Clément Cabanetos and Jean Roncali},

url = {https://onlinelibrary.wiley.com/doi/10.1002/adom.202000420},

doi = {10.1002/adom.202000420},

issn = {2195-1071, 2195-1071},

year  = {2020},

date = {2020-07-01},

urldate = {2024-11-16},

journal = {Advanced Optical Materials},

volume = {8},

number = {13},

pages = {2000420},

abstract = {Abstract 

 A series of simple donor–acceptor molecules consisting of an oligo‐oxyethylene (OOE) 

 N 

 ‐substituted diphenylamine connected to a dicyanovinyl (DCV) acceptor group by a thienyl π‐conjugating spacer are synthesized. Amorphous deep‐red freshly cast thin films rapidly evolve towards an almost colorless pale beige poly‐crystalline stable material from which a deep‐red photoluminescent state can be switched‐on by mechanical stimulation. The effects of the length of the OOE chain on the molecular packing of the material and on the dynamics of the recovery process and aggregation in solution are analyzed. Crystallographic results show that the length of the OOE chain directly controls the molecular packing from head‐to‐tail arrangement of the dipoles for short chain to co‐facial dimers leading to a non‐centrosymmetric material with nonlinear optics (NLO) activity for the longer ones. The analysis of the dynamics of the self‐recovery process of thin films and of molecular aggregation in solution shows that the dynamics of both processes is directly controlled by the length of the OOE chain. Since, as confirmed by optical and electrochemical results, the OOE substituents have strictly no influence on the electronic properties of the π‐conjugated system, the observed effects are unambiguously related to changes in intermolecular interactions.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{josse_bromination_2018,

title = {Bromination of the benzothioxanthene Bloc: toward new π-conjugated systems for organic electronic applications},

author = {Pierre Josse and Shi Li and Sergey Dayneko and Damien Joly and Antoine Labrunie and Sylvie Dabos-Seignon and Magali Allain and Benjamin Siegler and Renaud Demadrille and Gregory C. Welch and Chad Risko and Philippe Blanchard and Clément Cabanetos},

url = {https://xlink.rsc.org/?DOI=C7TC05245F},

doi = {10.1039/C7TC05245F},

issn = {2050-7526, 2050-7534},

year  = {2018},

date = {2018-01-01},

urldate = {2024-11-16},

journal = {Journal of Materials Chemistry C},

volume = {6},

number = {4},

pages = {761–766},

abstract = {The synthesis for monobrominated benzothioxanthene is reported, which is then employed in common palladium catalyzed coupling reactions for novel organic semiconductors. 

 , 

 A selective and efficient method to afford a monobrominated benzothioxanthene ( 

 Br-BTXI 

 ) derivative is reported. 

 Br-BTXI 

 was extensively employed in common palladium catalyzed coupling reactions. Finally, as a proof of concept, a 

 BTXI 

 based molecular donor was synthesized and evaluated in bulk heterojunction solar cells.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{josse_enantiopure_2017,

title = {Enantiopure versus Racemic Naphthalimide End‐Capped Helicenic Non‐fullerene Electron Acceptors: Impact on Organic Photovoltaics Performance},

author = {Pierre Josse and Ludovic Favereau and Chengshuo Shen and Sylvie Dabos‐Seignon and Philippe Blanchard and Clément Cabanetos and Jeanne Crassous},

url = {https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.201701066},

doi = {10.1002/chem.201701066},

issn = {0947-6539, 1521-3765},

year  = {2017},

date = {2017-05-01},

urldate = {2024-11-16},

journal = {Chemistry – A European Journal},

volume = {23},

number = {26},

pages = {6277–6281},

abstract = {Abstract 

 Impact of the enantiopurity on organic photovoltaics (OPV) performance was investigated through the synthesis of racemic and enantiomerically pure naphthalimide end‐capped helicenes and their application as non‐fullerene molecular electron acceptors in OPV devices. A very strong increase of the device performance was observed by simply switching from the racemic to the enantiopure forms of these π‐helical non‐fullerene acceptors with power conversion efficiencies jumping from 0.4 to about 2.0 % in air‐processed poly(3‐hexylthiophene)‐based devices, thus highlighting the key role of enantiopurity in the photovoltaic properties.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{josse_phthalimide_2016,

title = {Phthalimide end-capped thienoisoindigo and diketopyrrolopyrrole as non-fullerene molecular acceptors for organic solar cells},

author = {Pierre Josse and Clément Dalinot and Yue Jiang and Sylvie Dabos-Seignon and Jean Roncali and Philippe Blanchard and Clément Cabanetos},

url = {https://xlink.rsc.org/?DOI=C5TA09171C},

doi = {10.1039/C5TA09171C},

issn = {2050-7488, 2050-7496},

year  = {2016},

date = {2016-01-01},

urldate = {2024-11-16},

journal = {Journal of Materials Chemistry A},

volume = {4},

number = {1},

pages = {250–256},

abstract = {Two acetylene-bridged molecules, built by grafting phthalimides on thienoisoindigo ( 

 TII 

 ) and diketopyrrolopyrrole ( 

 DPP 

 ) blocks, have been synthesized, characterized and evaluated as electron acceptor materials in air-processed inverted organic solar cells. 

 , 

 Two acetylene-bridged molecules, built by grafting phthalimides on thienoisoindigo ( 

 TII 

 ) and diketopyrrolopyrrole ( 

 DPP 

 ) blocks, have been synthesized, characterized and evaluated as electron acceptor materials in air-processed inverted organic solar cells. Once blended with poly(3-hexylthiophene), power conversion efficiencies (PCEs) of 

 ca. 

 0.4% and 3.3% were achieved for 

 TII 

 and 

 DPP 

 based devices, respectively. To the best of our knowledge these PCEs (i) rank amongst the highest reported so far for diketopyrrolopyrrole based acceptors and (ii) make this contribution the very first example of thienoisoindigo based materials used as non-fullerene electron acceptors.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}